急性毒性白质脑病

来源：双语学影像；本期病例选自AJNRCaseoftheWeek

FatimaMubarak,ShayanAnwar,ZafarSajjadDepartmentofRadiology,AgaKhanUniversityHospitalKarachi,Pakistan

A29-year-oldmanwithadvancedcarcinomaoftheesophagus.Onday4of5-FUinfusionthepatientdevelopedconfusionandaphasiawithoutmotorweakness.

29岁男性，进展性食道癌患者。5-FU治疗第4天出现意识不清、失语，肌力正常。

Initialstudy,axialT2WI(A)demonstratesdiffuseabnormalincreasedT2-weightedsignalinvolvingthedeepandsubcorticalwhitematter,sparingtheU-fibers,associatedwithabnormalrestricteddiffusiononDWI.Inthefollow-upstudy,followingdiscontinuationof5-FU,thereis